Senior Clinical Data Manager

DICE is a leading CRO with over 35 years of experience focused that serves biotech and big pharma companies in Europe and the US. In order to support our growth, we are looking to hire a Senior Clinical Data Manager.

As a Senior Clinical Data Manager you will be the primary point of contact for all data management activities across assigned clinical trials. You will lead the full life cycle of clinical data—from protocol review and database design to data cleaning, database lock, and regulatory submission. This sponsor-dedicated role requires hands-on execution, strategic oversight and cross-functional collaboration to ensure high-quality, timely, and compliant data delivery.

Responsibilities

End-to-End Data Management Leadership

• Serve as the lead data manager for multiple clinical studies across phases I–IV.
• Own the data strategy, timelines, and deliverables from study start-up through close-out.
• Collaborate directly with the sponsor to align on data expectations and priorities.

Study Start-Up

• Review protocols and contribute to Case Report Form (CRF) design.
• Implement electronic Data Capture (EDC) system setup. Oversee validation, and user acceptance testing.
• Develop and maintain Data Management Plans (DMPs), edit check specifications, and CRF completion guidelines.

Data Cleaning & Oversight

• Monitor data quality and query resolution based on the data validation plans.
• Perform medical coding (MedDRA, WHO-DD) and SAE/AE reconciliation.
• Prepare, lead and follow-up on data review meetings and ensure timely issue escalation and resolution.

Database Lock & Submission

• Contribute to and coordinate final data cleaning and lock activities.
• Ensure readiness for statistical analysis and regulatory submission.
• Provide input into Clinical Study Reports (CSRs) and submission packages.

Vendor & Team Management

• Manage external vendors (EDC providers, labs, ….) and ensure performance meets sponsor standards.
• Mentor junior data managers and contribute to process improvement initiatives.

Qualifications and skills

• Master’s degree in Life Sciences, Data Science, or related field.
• Minimum 10 years of clinical data management experience, preferably in a sponsor-facing role.
• Strong knowledge of ICH-GCP, CDISC standards, and regulatory requirements.
• Proficiency in EDC systems (e.g., Medidata Rave, Oracle InForm, Veeva).
• Knowledge of SAS or Python is considered as a plus.
• Excellent communication, leadership, and project management skills.
• Experience with complex, multi-site global trials.
• Familiarity with oncology is considered as a plus
• Ability to work independently while fostering team collaboration.
• Able and willing to perform hands-on work: creation of deliverables, QA and QC of deliverables of team members.
• Strategic mindset with attention to operational detail. Knowledge of project details, while maintaining a high level view on project milestones and dependencies.

Our offer

DICE is a clinical research organization (CRO), that supports clinical studies for pharmaceutical and biotechnology companies. We offer full service projects delivery to our sponsors, and have an internal team that is specialized in clinical data management, biostatistics, central imaging review, medical writing and medical monitoring.

If you work with us then we can offer this package:

• A driver’s seat position in clinical research
• A young and dynamic work environment with close contact to our sponsors
• Possibility to grow with and within our company
• An attractive salary with lots of extras, including a long term incentive plan based on company targets
• An easy to reach office
• Possibilities to work from home
• A personal development path with tailored courses and trainings

Take your career to the next level, and apply now. Email recruitment@dice-cro.com